Preparation and Property Study of CMCS Complexes

To further enhance the carboxymethyl chitosan (collectively, carboxymethyl chitosan, CMCS) water-soluble and effect of coagulation and hemostatic, O-carboxymethyl chitosan (O-CMCS) and N,O-carboxymethyl chitosan (CMCS) are prepared by carboxymethyl chitosan modification under alkaline conditions, then Folic Acid-O-carboxymethyl chitosan (FA-O-CMCS) and Ca-nanocarboxymethyl chitosan(Ca-nmCMCS) are prepared by compounding folic acid and Ca 2+, respectively. The samples are characterized by Infrared spectrum(IR), X-ray diffraction(XRD) and scanning electron microscope (SEM), and compared with each other, with the results showing as follows: FA-O-CMCS and Ca-nmCMCS are successfully synthesized respectively. Comparison of the two results shows that Ca-nmCMCS is more stable, and has smaller and more uniform particle size about 27.4 nm, better dispersion without adhesion and stronger crystalline structure corresponding to the result of the solubility. But, the coagulation and hemostasis time of FA-O-CMCS is shorter than Ca-nmCMCS, and the former has the better effects of rapid coagulation and hemostasis. This provids a wide range of prospects for the application of Ca-nmCMCS and FA-O-CMCS.