Phytochemical Evaluation, Anti-obesity and Antihyperlipidemic Effects of Combined Administration of Green Coffee, Cinnamon and Ginger

This study aims to evaluate anti-obesity and antihyperlipidemic effects of individual and combined administration of ginger, cinnamon and green coffee on the hyperlipidimic rats. It is the first report dealing with the effects of the combined administration of these three plants as anti-obesity and antihyperlipidemic agents. Sprague-Dawley rats were used, where they divided into 6 groups (7 rats each). Group 1 was kept as a normal control, while the other groups fed on high-fat diet to induce obesity and hyperlipidemia for 4 weeks. Group 2 positive control that was kept obese, while other groups were orally given individual and combined powders of ginger, cinnamon and green coffee in doses 200mg/kg, respectively, for 6 weeks, At the end of the experiment, body weight of rats were recorded. Blood samples were collected for analyses. The results showed that each of individual and combined administration of these plants significantly (P<0.05) decreased the body weight and serum lipids including total lipid, triglyceride and low density lipoprotein when compared with positive control group, while they significantly (P<0.05) increased high density lipoprotein when compared with positive control group. Furthermore, our study showed that the combination of these three plants exhibited better effects than when compared to the individual powder of the plants. In this study we compared the effects of separated and combined administration of cinnamon bark, ginger root, green coffee beans as anti-obesity and antihyperlipidemic agents. The separated and combined administration exhibited significant anti-obesity and antihyperlipidemic effects in obese and hyperlipidemic rats, while the combined administration showed more powerful effects. Previous reports on cinnamon, ginger and green coffee as separately administered were thus confirmed; however, this is, to our knowledge, the first report dealing with the combined form of the three plants. Such combined administration might be useful in developing natural food additives to help address obesity and hyperlipidemia.