Correlation of TAZ Immunohistochemistry Expression and Breast Carcinoma

Overexpression of TAZ induces cell transformation and tumor-forming ability in mammary epithelial cells. The deactivation of the Hippo pathway, which leads to up regulation of YAP and TAZ is frequently observed in many human cancers. The study samples included seventy four formalin-fixed, paraffin embedded tissue blocks which have been diagnosed as forty four cases of breast carcinoma and their lymph nodes. In the present study from 74 total cases, 33cases (44.6%) were showing TAZ marker positive while 41cases (55.4%) were showing negative immunohistochemistry for TAZ marker. Sub classification of malignant cases, 11 malignant breast cancer cases (25%) showed no TAZ expression, while 20 malignant cases (45.5%) were strongly positive for TAZ expression. There is significant correlation between breast carcinoma grade, stage and TAZ expression