In the present study, we analysed the results from the use of serological tests for the evaluation of the antibody response to SARS-CoV-2 virus, with the aim of verifying the seroprevalence for SARS-CoV-2 virus infection in Rome. Evaluations related to the seroprevalence are important for defining the epidemiological parameters of this disease. We therefore analysed the data deriving from 1586 subjects, residing in the geographical area of Rome, subjected to a rapid test, capable of detecting the presence of specific IgM and IgG class antibodies directed against the SARS-CoV-2 virus. Among the 1586 cases, 83 had positive conversion of IgM antibody and/or IgG antibody and 1503 tested negative. Out of 83 positive cases, 48% (40/83) samples resulted positively for both IgM and IgG, while 45% (37/83) were positive for IgG only, and 7% (6/83) for IgM only. The prevalence of anti-SARS-CoV-2 antibodies in the considered geographical area was 5% (83/1586), and 54% (45/83) of our population was an asymptomatic carrier. The study was performed to better evaluate the population prevalence in the studied geographic area. To our knowledge, this is the first study carried out in the Lazio region reporting data related to the asymptomatic carriers.
References
[1]
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., et al. (2020) A Novel Coronavirus from Patients with Pneumonia in China, 2019. The New England Journal of Medicine, 382, 727-733. https://doi.org/10.1056/NEJMoa2001017
[2]
Lu, H., Stratton, C.W. and Tang, Y.W. (2020) Outbreak of Pneumonia of Unknown Etiology in Wuhan, China: The Mystery and the Miracle. Journal of Medical Virology, 92, 401-402. https://doi.org/10.1002/jmv.25678
[3]
Winter, A.K. and Hegde, S.T. (2020) The Important Role of Serology for COVID-19 Control. The Lancet Infectious Diseases, 20, 758-759. https://doi.org/10.1016/S1473-3099(20)30322-4
[4]
Margiotti, K., Cupellaro, M., Emili, S., Mesoraca, A. and Giorlandino, C. (2020) Evaluation of a Rapid Igm-Igg Combined Antibody Test for Sars-Cov-2 Infection: Single Italian Center Study. American Journal of Infectious Diseases, 16, 85-88. https://doi.org/10.3844/ajidsp.2020.85.88
[5]
Matricardi, P.M., Dal Negro, R.W. and Nisini, R. (2020) The First, Holistic Immunological Model of COVID-19: Implications for Prevention, Diagnosis, and Public Health Measures. Pediatric Allergy and Immunology, 31, 454-470. https://doi.org/10.1111/pai.13271
[6]
Henrickson, S.E. (2020) Learning from Our Immunological History: What Can SARS-CoV Teach Us about SARS-CoV-2? Science Immunology, 5, eabb8618. https://doi.org/10.1126/sciimmunol.abb8618
[7]
Mair-Jenkins, J., Saavedra-Campos, M., Baillie, J.K., Cleary, P., Khaw, F.M., Lim, W.S., et al. (2015) The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-Analysis. The Journal of Infectious Diseases, 211, 80-90. https://doi.org/10.1093/infdis/jiu396
[8]
Pan, Y., Li, X., Yang, G., Fan, J., Tang, Y., Zhao, J., et al. (2020) Serological Immunochromatographic Approach in Diagnosis with SARS-CoV-2 Infected COVID-19 Patients. Journal of Infection, 81, E28-E32. https://doi.org/10.1016/j.jinf.2020.03.051
[9]
Xiao, D.A.T., Gao, D.C. and Zhang, D.S. (2020) Profile of Specific Antibodies to SARS-CoV-2: The First Report. Journal of Infection, 81, 147-178. https://doi.org/10.1016/j.jinf.2020.03.012
[10]
He, J., Hu, P., Gao, Y., Zheng, S., Xu, C., Liu, R., et al. (2020) Comparison and Application of Different Immunoassay Methods for the Detection of SARS-CoV-2. Journal of Medical Virology, 92, 2777-2784. https://doi.org/10.1002/jmv.26187
[11]
Kellam, P. and Barclay, W. (2020) The Dynamics of Humoral Immune Responses Following SARS-CoV-2 Infection and the Potential for Reinfection. Journal of General Virology. https://doi.org/10.20944/preprints202004.0377.v1
[12]
Wu, L.P., Wang, N.C., Chang, Y.H., Tian, X.Y., Na, D.Y., Zhang, L.Y., et al. (2007) Duration of Antibody Responses after Severe Acute Respiratory Syndrome. Emerging Infectious Diseases, 13, 1562-1564. https://doi.org/10.3201/eid1310.070576
[13]
Edridge, A.W.D., Kaczorowska, J., Hoste, A.C.R., et al. (2020) Seasonal Coronavirus Protective Immunity Is Short-Lasting. Nature Medicine, 26, 1691-1693. https://doi.org/10.1038/s41591-020-1083-1
[14]
Pan, X., Chen, D., Xia, Y., Wu, X., Li, T., Ou, X., et al. (2020) Asymptomatic Cases in a Family Cluster with SARS-CoV-2 Infection. The Lancet Infectious Diseases, 20, 410-411. https://doi.org/10.1016/S1473-3099(20)30114-6
