Objectives: To study the change of CD16 + 56 in zona. Materials and Methods: 62 zona patients admitted at Inpatient Department of Dermatology, Venereology Allergy, 108 Military Central Hospital, and 30 healthy volunteers who were matched for age and sex participated in this study. Prospective, cross-sectional study with controls was conducted. We measured the number of CD16 + CD56 by flow cytometry using FACS Callibur. Results: The mean level of CD16 + 56 in zona patients was 253 ± 200 (106 cells/l), which was lower than that of control group but then increased after treatment. The change of CD16 + 56 did not correlate with patients’ age. Patients who were in severe condition or had affected size from 3% or more had a lower number of CD16 + 56 than control group. Conclusion: The number of CD16 + 56 in zona patients were lower than that of healthy people.
References
[1]
Chu, A.T. (2004) Studying the Clinical and Subclinical Characteristics in Diagnosing and Predicting the Outcome of Sepsis and Its Treatment Result. Doctoral Thesis, Military Medical Academy.
[2]
Nguyễn Thị Thu Hoài (2018) Evaluating the Relationship between Clinical Characteristics and Metabolic Disorders (Glucid, Lipid, Protid) at Dermatology Department, Thai Nguyen Central General Hospital. Science & Technology, 89, 35-40.
[3]
Barton, J.C. and Bertoli, L.F. (2012) Predictors of Shingles Reports at Diagnosis of Common Variable Immunodeficiency and Selective Immunoglobulin G Subclass Deficiency in 212 Alabama Adults. Infectious Disease Reports, 4, e34. https://doi.org/10.4081/idr.2012.e34
[4]
Campbell, T.M., McSharry, B.P., Steain, M., Ashhurst, T.M., Slobedman, B., et al. (2018) Varicella Zoster Virus Productively Infects Human Natural Killer Cells and Manipulates Phenotype. PLOS Pathogens, 14, e1006999. https://doi.org/10.1371/journal.ppat.1006999
[5]
Cauda, R., Prasthofer, E.F., Tilden, A.B., Whitley, R.J. and Grossi, C.E. (1987) T-Cell Imbalances and NK Activity in Varicella-Zoster Virus Infections. Viral Immunology, 1, 145-152. https://doi.org/10.1089/vim.1987.1.145
[6]
De Pelsmaeker, S., Romero, N., Vitale, M. and Favoreel, H.W. (2018) Herpesvirus Evasion of Natural Killer Cells. Journal of Virology, 92, e02105-17. https://doi.org/10.1128/JVI.02105-17
[7]
Etzioni, A., Eidenschenk, C., Katz, R., Beck, R., Casanova, J.L., et al. (2005) Fatal Varicella Associated with Selective Natural Killer Cell Deficiency. The Journal of Pediatrics, 146, 423-425. https://doi.org/10.1016/j.jpeds.2004.11.022
[8]
Gerada, C., Campbell, T.M., Kennedy, J.J., McSharry, B.P., Steain, M., et al. (2020) Manipulation of the Innate Immune Response by Varicella Zoster Virus. Frontiers in Immunology, 11, 1. https://doi.org/10.3389/fimmu.2020.00001
[9]
Ihara, T., Kamiya, H., Starr, S.E., Arbeter, A.M. and Lange, B. (1989) Natural Killing of Varicella-Zoster Virus (VZV)-Infected Fibroblasts in Normal Children, Children with VZV Infections, and Children with Hodgkin’s Disease. Acta Paediatrica Japonica, 31, 523-528. https://doi.org/10.1111/j.1442-200X.1989.tb01349.x
[10]
Kim, C.K., Choi, Y.M., Bae, E., Jue, M.S., So, H.S., et al. (2018) Reduced NK Cell IFN-Gamma Secretion and Psychological Stress Are Independently Associated with Herpes Zoster. PLoS ONE, 13, e0193299. https://doi.org/10.1371/journal.pone.0193299
[11]
Laing, K.J., Ouwendijk, W.J.D., Koelle, D.M. and Verjans, G (2018) Immunobiology of Varicella-Zoster Virus Infection. The Journal of Infectious Diseases, 218, S68-S74. https://doi.org/10.1093/infdis/jiy403
[12]
Patton, K.T. (2015) Support and Movement. In: Anatomy and Physiology, Elsevier Health Sciences, Amsterdam, 202.
[13]
See, D.M., Khemka, P., Sahl, L., Bui, T. and Tilles, J.G. (1997) The Role of Natural Killer Cells in Viral Infections. Scandinavian Journal of Immunology, 46, 217-224. https://doi.org/10.1046/j.1365-3083.1997.d01-121.x
[14]
Vossen, M.T., Biezeveld, M.H., de Jong, M.D., Gent, M.R., Baars, P.A., et al. (2005) Absence of Circulating Natural Killer and Primed CD8+ Cells in Life-Threatening Varicella. The Journal of Infectious Diseases, 191, 198-206. https://doi.org/10.1086/426866
[15]
Wolff, K. and Johnson, R.A. (2009) Herpes Zoster. In: Color Atlas & Synopsis of Dermatology, 6th Edition, McGraw Hill, London, 837-845.
[16]
Arvin, A.M. (2008) Humoral and Cellular Immunity to Varicella-Zoster Virus: An Overview. The Journal of Infectious Diseases, 197, S58-S60. https://doi.org/10.1086/522123
