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Functional Materials Surface Modified for the Capture of Circulating Tumor Cells

DOI: 10.12677/NAT.2021.111001, PP. 1-7

Keywords: 微流控芯片,循环肿瘤细胞,抗体修饰,静电纺丝,捕获
Micro-Fluidic Chip
, Circulating Tumor Cells, Antibody Modification, Electr-Ostatic Spinning, Capture

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In this study, circulating tumor cells (McF-7) were used as the research object. Microcolumns of micron size were prepared by soft photolithography. Using electrostatic spinning technology, PLGA nanofibers were spun on the microcolumnar substrates, then a micron-nanocomposite biological interface was prepared. Specific antibodies were modified on nanofibers, circulating tumor cells can be captured at this time. This research method combines microfluidic technology and electrostatic spinning technology. The three-dimensional microcolumn network scaffold structure is prepared to increase the capture space of cells, and the sensitivity of detection of circulating tumor cells was improved by modifying the nanofibers on the microstructure. This method greatly improves the detection efficiency of circulating tumor cells, and also provides a new research direction for clinical cancer detection.


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