|
|
儿童脑积水
|
Abstract:
儿童脑积水是小儿神经外科常见的并发症，临床上很多原因导致脑脊液吸收和分泌失调，进而出现脑室系统扩张，并对脑组织造成损害，造成儿童生长发育延迟或停滞。儿童作为特殊的群体，有其自身的特点。随着近些年分子生物学和基因检测方面的发展以及对脑积水遗传学的深入研究，让我们对脑积水有了更深入的认识。为了更好的应用于临床，本文主要对儿童脑积水的病因、诊断、临床表现及治疗进行综述。
Hydrocephalus in children is a common complication of pediatric neurosurgery. Various reasons lead to the imbalance of cerebrospinal fluid absorption and secretion, leading to ventricular system expansion, and damage to brain tissue, so that children’s growth and development delay or stagnation. Children as a special group, children have their own characteristics. With the development of molecular biology and gene detection in recent years and the in-depth research on the genetics of hydrocephalus, we have a deeper understanding of hydrocephalus. This article reviews the etiology, diagnosis, clinical manifestations and treatment of pediatric hydrocephalus.
| [1] | 程涛, 等. 儿童脑积水的生存质量评价[J]. 医药论坛杂志, 2011, 32(9): 195-197. |
| [2] | 李新星, 等. 脑室-腹腔分流术治疗婴幼儿脑积水的疗效分析[J]. 中华神经外科疾病研究杂志, 2014, 13(1): 55-58. |
| [3] | 江峰, 赵阳, 孙莲萍, 金惠明, 马杰. 婴幼儿阻塞性脑积水两种手术方式的疗效比较[J]. 临床小儿外科杂志, 2011, 10(1): 16-20. |
| [4] | Moritake, K., et al. (2007) Nationwide Survey of the Etiology and Associated Conditions of Prenatally and Postnatally Diagnosed Congenital Hydrocephalus in Japan. Neurologia Medico-Chirurgica, 47, 448-452.
https://doi.org/10.2176/nmc.47.448 |
| [5] | Tully, H.M. and Dobyns, W.B. (2014) Infantile Hydrocephalus: A Re-view of Epidemiology, Classification and Causes. European Journal of Medical Genetics, 57, 359-368. https://doi.org/10.1016/j.ejmg.2014.06.002 |
| [6] | Adle-Biassette, H., et al. (2013) Neuropathological Review of 138 Cases Genetically Tested for X-Linked Hydrocephalus: Evidence for Closely Related Clinical Entities of Unknown Mo-lecular Bases. Acta Neuropathologica, 126, 427-442. https://doi.org/10.1007/s00401-013-1146-1 |
| [7] | Assémat, E., et al. (2013) The Multi-PDZ Domain Protein-1 (MUPP-1) Expression Regulates Cellular Levels of the PALS-1/PATJ Polarity Complex. Experimental Cell Research, 319, 2514-2525.
https://doi.org/10.1016/j.yexcr.2013.07.011 |
| [8] | Feldner, A., et al. (2017) Loss of Mpdz Impairs Ependymal Cell Integrity Leading to Perinatal-Onset Hydrocephalus in Mice. EMBO Molecular Medicine, 9, 890-905. https://doi.org/10.15252/emmm.201606430 |
| [9] | Ishida-Takagishi, M., et al. (2012) The Dishevelled-Associating Protein Daple Controls the Non-Canonical Wnt/Rac Pathway and Cell Motility. Nature Communications, 3, 859. https://doi.org/10.1038/ncomms1861 |
| [10] | McAllister, J.P. (2012) Pathophysiology of Congenital and Neonatal Hydrocephalus. Seminars in Fetal & Neonatal Medicine, 17, 285-294. https://doi.org/10.1016/j.siny.2012.06.004 |
| [11] | Lattke, M., Magnutzki, A., Walther, P., Wirth, T. and Baumann, B. (2012) Nuclear Factor κB Activation Impairs Ependymal Ciliogenesis and Links Neuroinflammation to Hydrocephalus Formation. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32, 11511-11523.
https://doi.org/10.1523/JNEUROSCI.0182-12.2012 |
| [12] | Yung, Y.C., et al. (2011) Lysophosphatidic ACID Sig-naling May Initiate Fetal Hydrocephalus. Science Translational Medicine, 3, 99ra87. https://doi.org/10.1126/scitranslmed.3002095 |
| [13] | Lee, L. (2013) Riding the Wave of Ependymal Cilia: Genetic Susceptibility to Hydrocephalus in Primary Ciliary Dyskinesia. Journal of Neuroscience Research, 91, 1117-1132. https://doi.org/10.1002/jnr.23238 |
| [14] | Mayfrank, L., et al. (1997) Ventricular Dilatation in Experimental Intra-ventricular Hemorrhage in Pigs. Characterization of Cerebrospinal Fluid Dynamics and the Effects of Fibrinolytic Treat-ment. Stroke, 28, 141-148.
https://doi.org/10.1161/01.STR.28.1.141 |
| [15] | Pang, D., Sclabassi, R.J. and Horton, J.A. (1986) Lysis of Intra-ventricular Blood Clot with Urokinase in a Canine Model: Part 1. Canine Intraventricular Blood Cast Model. Neurosur-gery, 19, 540-546.
https://doi.org/10.1227/00006123-198610000-00008 |
| [16] | Cherian, S., Whitelaw, A., Thoresen, M. and Love, S. (2004) The Pathogenesis of Neonatal Post-Hemorrhagic Hydrocephalus. Brain Pathology (Zurich, Switzerland), 14, 305-311. https://doi.org/10.1111/j.1750-3639.2004.tb00069.x |
| [17] | Flood, C., et al. (2001) Transforming Growth Factor-beta1 in the Cerebrospinal Fluid of Patients with Subarachnoid Hemorrhage: Titers Derived from Exogenous and Endogenous Sources. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 21, 157-162.
https://doi.org/10.1097/00004647-200102000-00007 |
| [18] | Ibrahim, I., et al. (2008) Hydrocephalus Following Bi-lateral Jugular Venous Thrombosis in a Child: Case Report and Review of the Literature. Pediatric Neurosurgery, 44, 68-70. https://doi.org/10.1159/000110667 |
| [19] | Maller, V.V. and Gray, R.I. (2016) Noncommunicating Hydro-cephalus. Seminars in Ultrasound, CT, and MR, 37, 109-119. https://doi.org/10.1053/j.sult.2015.12.004 |
| [20] | Wright, Z., Larrew, T.W. and Eskandari, R. (2016) Pediatric Hy-drocephalus: Current State of Diagnosis and Treatment. Pediatrics in Review, 37, 478-490. https://doi.org/10.1542/pir.2015-0134 |
| [21] | 韩刚, 林志雄, 何理盛. 儿童脑积水外科治疗的新进展[J]. 医学综述, 2010, 16(8): 1218-1220. |
