分子记忆对基因表达过程中的能量消耗影响
The Influence of Molecular Memor on Energy Consumption in Gene Expression

一方面,分子记忆广泛存在于基因表达过程中; 另一方面,由热动力学的观点,基因表达过程必然消耗能量.这引起一个未探索的问题:分子记忆如何影响基因表达的能量消耗.由此,通过分析一个代表性的、带记忆的基因表达模型,结果发现:分子记忆越强,基因表达消耗越多能量; 极小势和能量消耗之间存在反比例关系,这表明基因表达越稳定,需要消耗的能量越多.这些结果表明分子记忆是一个不可忽略的因素,它能有意义地影响基因表达过程中的能量消耗.
On one hand,molecular memory exists extensively in gene expression.On the other hand,gene expression necessarily consumes energy from the viewpoint of thermodynamics.This raises an unexplored issue how molecular memory affects energy consumption in gene expression.By analyzing a representative stochastic model of gene expression with molecular memory,it is found that the stronger is the molecular memory,the more is the energy consumed.In addition,it is found that there is an inverse relationship between potential minimum and energy consumption,implying that more stable gene expression needs more energy consumption.These results indicate that molecular memory is an unneglectable factor and can significantly impact energy consumption in gene expression