2-(4-氯苯基)-4-(4-甲氧基苯基)喹唑啉抑制微囊藻生长的研究及应用前景探究
The Effects of CMQ on Growth of Colonial Microcystis aeruginosa and Its Practical Application Perspective in the Control of Cyanobacterial Blooms

近年来，随着水体富营养化程度加剧，蓝藻水华现象已成为世界性的灾难问题，有效地控制蓝藻水华对于保证水体水质安全和水体生态修复至关重要.喹唑啉类化合物，作为一类生态安全性好且易于降解的生物碱类化合物，具有广谱的抗菌生物活性和药用价值，最近研究发现这类化合物具有潜在的抑制微囊藻生长和控制蓝藻水华的能力.通过2-（4-氯苯基）-4-（4-甲氧基苯基）喹唑啉（ CMQ）对群体状的铜绿微囊藻（Microcystis aeruginosa）的生长影响实验，发现CMQ在大于5.0 mg？L-1的浓度条件下，对微囊藻有强烈抑制效果，4 d内CMQ对微囊藻细胞的50；生长抑制浓度（ EC50）为1.93 mg？L-1.通过对微囊藻的群体形态和大小的变化观察，结果表明CMQ能够降解M. aeruginosa群体并引起群体颗粒变小，导致明显的群体沉降.
Along with increasing eutrophication in recent years,massive cyanobacterial blooms have become a severe environmental problem in freshwaters worldwide. Therefore,developing an effective method to control the cyanobac-terial bloom essential to guarantee the water quality security and to recover the aquatic ecosystem. Quinazoline deriv-atives,endowed with a broad spectrum of biological activities and therapeutic properties,had a potential ability to in-hibit the groth of Microcystis and control the cyanobacterial blooms. In this study,it was shown that CMQ could in-tensely inhibit the growth of M. aeruginosa groups at the concentration of higher than 5. 0 mg？L-1 of CMQ,with EC50 for 4 d as 1. 93 mg？L-1. The change of colony morphology and volume size in Microcystis aeruginosa,also suggested that CMQ could break down the M. aeruginosa colonies and cause the smaller size of Microcystis colonies, and led to obvious settlement of these colonies. Based on the results that CMQ had exhibited efficient antialgal activ-ities,it is further implicated that CMQ have apractical application perspective in the control of cyanobacterial blooms