摘要 目的 探讨血清中补体C1q/C3比值与冠心病（CHD）发病的关系。 方法 选取2018年12月―2019年3月在我院住院并经冠状动脉造影检查确诊为CHD的患者67例（CHD组），依据Gensini评分将CHD组分为冠状动脉轻度狭窄组（B组）36例，冠状动脉重度狭窄组（C组）31例；同期因胸痛、胸闷及憋气等症状住院但经冠状动脉造影及其他检查排除CHD者34例为对照组（A组），检测各组血清中C1q、C3水平，计算C1q/C3比值,并分析C1q/C3比值与CHD发病的关系。 结果 CHD组血清中C1q水平及C1q/C3比值与A组相比明显降低，差异有显著性（t=2.365、3.281，P＜0.05）；C组C1q/C3比值较A组显著降低，差异有显著性（F=8.055，P＜0.05）。经二分类Logistic回归分析结果显示，C1q/C3比值与CHD发病密切相关（95%CI=0.947～0.994，P＜0.05）。 结论 CHD患者血清中C1q/C3比值显著降低，可能是CHD发病的保护性因素，对动脉粥样硬化严重程度有潜在的预测价值。 Abstract：Objective To investigate the association between serum C1q/C3 ratio and coronary heart disease (CHD). Methods A total of 67 patients who were hospitalized in our hospital from December 2018 to March 2019 and were diagnosed with CHD by coronary angiography were enrolled as CHD group, and according to the Gensini score, they were divided into mild coronary artery stenosis group (group B with 36 patients) and severe coronary artery stenosis group (group C with 31 patients). Another 34 patients who were hospitalized due to chest pain, chest distress, and suffocation during the same period of time and did not have CHD were enrolled as control group (group A). Serum levels of C1q and C3 were measured, C1q/C3 ratio was calculated, and the association between C1q/C3 ratio and CHD was analyzed. Results Compared with group A, the CHD group had significant reductions in serum C1q and C1q/C3 ratio (t=2.365,3.281,P<0.05), and group C also had a significant reduction in C1q/C3 ratio (F=8.055,P<0.05). The binary logistic regression analysis showed that C1q/C3 ratio was closely associated with CHD (95%CI=0.947-0.994,P<0.05). Conclusion There is a significant reduction in C1q/C3 ratio in patients with CHD, which may be a protective factor against CHD and has a potential value in predicting the severity of atherosclerosis
