Study of Plasma Adiponectin and Insulin Resistance in Subjects with Non-Alcoholic Fatty Liver Disease.

Background: The relation between insulin resistance and the level of plasma adiponectin hormone in patients with non-alcoholic fatty liver disease (NAFLD) was highly suggested due to the high prevalence of NAFLD in obese and diabetic patients. Objectives: This study was conducted to explore the link between the three factors, NAFLD, insulin resistance and the level of plasma adiponectin. Methods: The study was run on patients with the diagnosis of NAFLD, depending on the ultrasound findings, with exclusion of diabetic, obese, and alcoholic patients. The level of insulin resistance was evaluated using the homeostasis model assessment (HOMA IR) index, and the level of plasma adiponectin was measured as well. Results: There was a significant degree of insulin resistance in patients with NAFLD, with a significantly lower levels of adiponetin hormone compared to the control group. Conclusion: This study reported lower plasma adiponectin levels in NAFLD patients that were inversely correlated with insulin resistance, which was markedly documented in the patients of NAFLD