New Onset of Multi-Drug Hypersensitivity Reaction after Successful Treatment of Hepatitis C with Ledipasvir-Sofosbuvir in CKD: A Case Report.

In recent years, multiple drug regimens are available for the safe and efficient treatment of Hepatitis C in a short period. There are case reports of drug reactions in patients treated with interferon Alfa-2b and ribavirin combination. However, there are no reports of hypersensitivity reactions to previously tolerated medication after eradication of HCV with the new regimen. Here we report a patient presenting with hypersensitivity reactions to multiple drugs, which were previously well tolerated, after the successful eradication of chronic Hepatitis C with the ledipasvir-sofosbuvir combination. The patient may have had an underlying hypersensitivity reaction to medications before his infection with Hepatitis C. Chronic Hepatitis C infection appears to exert an immunosuppressive effect which masks the hypersensitivity reaction. Complete eradication of viral load by the newly available drugs ledipasvir-sofosbuvir unmasked the immunosuppression. However, the immunomodulatory effect of the new drug cannot be excluded as a possible etiology. It is important to know that these hypersensitivity reactions can occur after the successful treatment of Hepatitis C and may cause lifethreatening reactions in patients