In vitro evaluation of antioxidant activity of Leucas plukenetii (Roth) Spreng

The present study was carried out to evaluate the antioxidant activities of methanolic extract of Leucas plukenetii (Roth) Spreng whole plant in various systems. The free radical scavenging potential was studied by using different antioxidants models of screening using vitamin C (5mM) as standard. About 200, 400, 600 & 800 μg/ml methanolic extract inhibited the FeSO4 induced lipid peroxidation in a dose dependent manner and showed IC50 value 536 ± 1.26 μg/ml. The methanolic fraction at 800 μg/ml exhibited significant antioxidant activity in ferrous sulphate induced lipid peroxidation and Superoxide scavenging models with simultaneous improvement in hepatic glutathione (10.31 ± 0.2906 μg GSH/mg of wet tissue) and catalase levels (121.81 ± 0.6306 μM of H2O2 consumed /min/mg tissue) compared to standard group. The results suggest that the methanolic extract of Leucas plukenetti Smith. Whole plant plays an important role in the modulation of oxidative stress