Anti-Hepatotoxic Activity of Mucuna Capitata Roxb. Extract Against Paracetamol Induced Hepatotoxicity

Herbal formulations available with a wide range of indications like protective to liver, hepatic regulator, as treatment for hepatic dysfunction, for hepatic regeneration as well as liver stimulant and tonic. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. Aim: The present study investigates the possible anti-hepatotoxic activity of Mucuna Capitata Roxb (MCR) against paracetamol induced hepatotoxicity in albino wistar rats. Methods: Alcoholic extract (80% Ethanol) of the MCR whole plant was used in the study. A comparison was also made between the actions of MCR extract and a known hepatoprotective drug silymarin. Preliminary phytochemical screening was carried. Bio-chemical parameters like SGOT, SGPT, SALP, Total bilirubin, Total protein and histopathological studies were used to evaluate the anti-hepatotoxic activity. Acute toxicity studies were carried out according to OECD (420) guidelines, 200mg and 400mg/kg BW doses were selected for the present study. Results: Effect of MCR found to be dose dependent and reduces the elevated levels of SGOT, SGPT, SALP, Total bilirubin and Total protein. 400mg/kg B.W. shows highly significant anti-hepatotoxic activity (P≤0.001 compared to Group-II). In histopathological studies, 400mg/kg B.W showed no significant necrosis. Conclusion: From the results, it is evident that MCR has significant anti-hepatotoxic activity against paracetamol induced hepatotoxicity in albino Wistar rats