Study the Immunomodulatory Effects of Combined Extracts of Sesbania grandiflora Flowers and Cocculus hirsutus Leaves on the Circulating Antibody Response

Polyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. We assessed the Immunomodulatory effects of a combination of extracts from Sesbania grandiflora flowers and Cocculus hirsutus leaves. In this work we detected the IgM and IgG levels in sera from mice treated with the HP-I, HP-II and HP-III against SRBC in ELISA methods at 0, 4, 7 and 14 days. In addition, we analyzed the phytochemical properties of the different herbal preparations. After oral administration of the dose of combined extract (100-400 mg/ kg b.w.) increase the serum antibody titers after four and seven days, suggesting immunostimulatory activity through modulation of B lymphocyte functions. These results suggested that HP-I from 1:1 of both plants contained several chemical compounds that possess positive modulator effects on the immune system