Solvent-free Knoevenagel Condensation over Amino Acid Amide based Ionic Liquid as an Efficient and Eco-friendly Catalyst

Solvent-free Knoevenagel condensation was carried out over 1-((4-chlorophenyl) amino)-1-oxopropan-2-aminium perchlorate based ionic liquid as an eco-friendly catalyst at room temperature. A wide range of aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. The most significant feature of this methodology is the condensation of aliphatic aldehydes and cyclic ketones, achieved very efficiently at room temperature under solvent-free conditions, which is difficult to achieve by conventional methods. Additionally, the catalyst is easily separable and recyclable without loss of activity.