Associating serum ghrelin with some indicative markers of type 2 diabetic in healthy obese men

Ghrelin is a gastrointestinal neuropeptide which plays an important role in appetite, food absorption and body weight regularization. In this study we intended to found serum ghrelin in relation to indicative markers of glucose levels in non-diabetic obese men. Forty eight obese sedentary males (age, 36 +/- 7 yr, BMI, 32.1 +/- 3.11 kg/m2) were enrolled to the study by voluntarily. Blood samples were obtained after a 12-hour overnight fast for measuring serum ghrelin, glucose, insulin of studied subjects. Homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-BF) was calculated by fasting insulin and glucose. A Pearson method used for determine relation between serum ghrelin with glucose and the other diabetic determinatives. The data of person analysis showed that there was no significant relationship between ghrelin with glucose and other diabetic inductive variables such as insulin, insulin resistance and beta cell function. In conclusion we can say that fasting glucose and the other type 2 diabetic determinatives does not affect by serum ghrelin in healthy obese males.