The effect of different types of exercise on plasma fibrinogen levels in non-athlete males

Coronary Artery Disease (CAD) is the number one killer of adults in the Iran. Plasma Fibrinogen is CAD risk factor that participation in both the atherogenic and thrombogenic processes. Long-term exercise training and physical activity favorably modified several of the conventional CAD risk factors. No such association has been consistently shown between regular physical activity and exercise training with plasma fibrinogen concentrations, and the effects of physical activity and exercises training on plasma fibrinogen were not clear. This study aimed to clarify whether endurance and resistance exercise training reduced plasma fibrinogen levels in non-athlete young males. This quasi-experimental study involved 36 voluntary participants that were randomly divided into three groups of 12 each, as follows: Endurance Training, Resistance Training and Control groups. Whole blood samples were collected from the left antecubital vein after 9–12 hours of fasting. The plasma concentrations of fibrinogen were measured using the chronometric method by Biomerio fully automated analyzer. Within-group comparisons of plasma fibrinogen were performed using two-tailed paired samples t test. Between-group comparisons of plasma fibrinogen were performed using one-way analysis of variance (ANOVA) and the Tukey Post Hoc test. Significant levels for all tests were set at p≤ 0.05. Between-group differences were significant in the plasma concentrations of fibrinogen [F (2, 33) = 3.963, p = 0.02*]. A plasma concentration of fibrinogen in endurance training group (212.91 ± 11.13) was significantly lower than control (235.25 ± 28.10) group (p=0.022). Within-group differences of the plasma fibrinogen concentrations were significant in endurance training group [t (11) = -4.22, p = 0.001**]. The results indicated that endurance exercise training does have desirable effects on the plasma levels of fibrinogen in non-athlete young males, but resistance exercise training does not have any desirable effects on the plasma levels of fibrinogen in non-athlete young males. More studies are required to clarify the optimal intensity, duration, and type of exercise to favorably modify plasma fibrinogen