Formulation and Evaluation of Timolol Maleate Transdermal Patches Using Various Permeation Enhancers

Objective: Our main aim was to formulating transdermal drug delivery systems of Timolol maleate of an anti-hypertensive drug using various polymer such as ethyl cellulose, eudragit RL100 and eudragit RS100. Methods: The patches of Timolol was prepared by solvent casting method using ethyl cellulose (EC), eudragit RL100 (ERL100) and eudragit RS100 (ERS100)polymer were used in various ratio (EC:ERL100 or EC:ERS100). Polymeric solution was prepared by dissolving ethyl cellulose into the required volume of acetone with continuous stirring (Sol. A) Then Add of eudragitRL100 or eudragit RS100 into the Sol. A with continuous stirring for homogeneous mixing (Sol.B). Drug (0.75%) was dissolved in water and incorporated into the sol. B. To improve the patch performance and drug release different type of permeation enhancer like Tween 80 or Span 80 were added whereas glycerin was used as a plasticizer. Results: The result of In- Vitro release kinetic for the optimized F5 formulation are represented in figure 4-7.It was observed that F5 follows the zero order R2 value were 0.990 which are higher than other model. Conclusion: It was concluded that this formulation follows zero order kinetics, which release drug in control manner and it is the ideal method of drug release to achieve pharmacological prolonged action