氢化诺卜基甲酰胺类化合物的合成与结构表征
The Synthesis and Structural Characterization of Hydronopylformamide Compounds

由氢化诺卜基溴(RBr)与镁反应制成格氏试剂,再与二氧化碳反应并经稀酸分解合成了氢化诺卜基甲酸(RCO2 H),后者与亚硫酰氯反应制成酰氯(RCOCl),再分别与氨、二甲胺、二乙胺、二异丙胺、六氢吡啶、吗啉等反应合成了6种氢化诺卜基甲酰胺类化合物,各化合物都用IR、1 H NMR、13C NMR与MS进行了结构表征.
Grignard reagent was prepared through the Grignard reaction of hydronopyl bromine and magnesium,and hydronopylformic acid was synthesized from the decompose reaction of diluted acid with carbon dioxide.Then hydronopylformyl chloride was obtained from the reaction of hydronopylformic acid and thionyl chloride.Finally,six kinds of hydronopylformamide compounds were synthesized from the reaction of hydronopylformyl chloride with ammonia,dimethylamine,diethylamine,diisopropylamine,hexahydropyridine and morpholine respectively.The structures of the products were characterized by IR,H NMR,C NMR and MS methods