摘要 目的 探索前庭性偏头痛患者脑灰质体积的变化，进一步研究前庭性偏头痛的发病机制。 方法 选取前庭性偏头痛患者20例为病例组,另选取年龄、性别、受教育程度匹配良好的20例健康人为对照组。应用基于体素的形态测量（VBM）方法分析比较两组研究对象全脑灰质体积的差异。 结果 与对照组相比，前庭性偏头痛患者灰质体积减小的脑区包括右侧颞上回和右侧中央后回（t=3.817、4.049,P<0.001）；前庭性偏头痛患者灰质体积增大的脑区包括右侧颞中回、右侧缘上回、右侧补充运动区（t=－4.627～－3.907，P<0.001）。 结论 前庭性偏头痛患者的疼痛相关脑区和涉及多感觉前庭处理脑区均发现灰质体积异常，这应该是前庭性偏头痛的神经生物学因素之一。 Abstract：Objective To investigate the change in gray matter volume in patients with vestibular migraine (VM) and the pathogenesis of VM. Methods A total of 20 patients with VM were enrolled as case group, and 20 healthy individuals matched for age, sex, and educational level were enrolled as control group. Voxel-based morphometry was used to analyze and compare gray matter volume between the two groups. Results Compared with the control group, the case group had a significant reduction in gray matter volume in the right superior temporal gyrus and the right posterior central gyrus (t=3.817,4.049,P<0.001), as well as a significant increase in gray matter volume in the right middle temporal gyrus, the right supramarginal gyrus, and the right supplementary motor area (t=-4.627--3.907,P<0.001). Conclusion In patients with VM, abnormal gray matter volume is observed in the pain-related regions and the multisensory vestibular processing regions, which may be one of the neurobiological factors for VM
