摘要 目的 探讨机械通气联合血必净注射液治疗急性呼吸窘迫综合征（ARDS）患者的效果。 方法 选取郑州人民医院2016年10月—2018年3月收治的92例ARDS患者作为研究对象，根据治疗方案分为观察组（46例）。与对照组（46例）。在常规综合治疗基础上，对照组给予机械通气治疗，观察组给予机械通气＋血必净注射液治疗。对比两组治疗前及治疗后第7天动脉氧合指标（动脉血氧饱和度（SaO2）、动脉血氧分压（PaO2）、氧合指数（PaO2/FiO2））、血清炎性因子指标（可溶性细胞间黏附分子-1（sICAM-1）、降钙素原（PCT））、血浆凝血功能指标（纤维蛋白原（FIB）、D-二聚体（D-D））、病情转归情况（急性生理与慢性健康评分（APACHEⅡ）、Murray肺损伤评分（MLIS）及预后情况（机械通气时间、ICU入住时间、第28天病死率）。 结果 观察组患者SaO2、PaO2、PaO2/FiO2治疗前后差值与对照组比较，差异有显著性（t=4.986～8.073，P＜0.05）。观察组患者血清sICAM-1、PCT治疗前后差值与对照组比较，差异有显著性（t=6.288、10.576，P＜0.05）。观察组血浆FIB、D-D治疗前后差值与对照组比较，差异有显著性（t=3.215、3.431，P＜0.05）。观察组APACHEⅡ评分、MLIS评分治疗前后差值与对照组比较，差异有显著性（t=3.174、4.254，P＜0.05）。观察组机械通气时间、ICU入住时间均短于对照组（t=4.497、6.514，P＜0.05）；第28天病死率与对照组比较差异无显著性（P＞0.05）。 结论 给予ARDS患者机械通气联合血必净注射液治疗，可有效改善患者动脉血气分析状况，降低机体炎症反应，并可纠正凝血异常，有利于促进患者病情缓解，减轻肺损伤，缩短机械通气时间与ICU入住时间，但尚无有效数据证实其可降低ARDS病死率。 Abstract：Objective To investigate the clinical effect of mechanical ventilation combined with Xuebijing injection in the treatment of patients with acute respiratory distress syndrome (ARDS). Methods A total of 92 ARDS patients who were admitted to Zhengzhou People’s Hospital from October 2016 to March 2018 were enrolled as subjects, and according to their treatment regimen, they were divided into observation group with 46 patients and control group with 46 patients. In addition to the conventional comprehensive treatment, the patients in the control group were given mechanical ventilation, and those in the observation group were given mechanical ventilation+Xuebijing injection. The two groups were compared in terms of arterial oxygenation indices \[arterial oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2), and oxygenation index (PaO2/FiO2)\], serum inflammatory factors \[soluble intercellular adhesion molecule-1 (sICAM-1) and procalcitonin (PCT)\], and plasma coagulation parameters \[fibrinogen (FIB) and D-dimer (DD)\] before treatment and on day 7 of treatment, as well as disease outcome \[Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score\], Murray Lung Injury Score (MLIS), and prognosis (duration of mechanical ventilation, length of ICU stay, and 28-day mortality rate). Results Compared with the control group, the observation group had significantly greater changes in SaO2, PaO2, and PaO2/FiO2 after treatment (t=4.986-8.073,P<0.05), as well as significantly greater changes in serum sICAM-1 and PCT (t=6.288,10.576,P<0.05), plasma FIB and DD (t=3.215,3.431,P<0.05), and APACHE Ⅱ and MLIS scores (t=3.174,4.254,P<0.05). The observation group had significantly shorter duration of mechanical ventilation and length of ICU
