Correlation between demographic factors and warfarin stable dosage in population of Western China

Objective: To investigate the correlation between warfarin stable dosage and demographic factors in patients undergoing valve replacement in Western China and then guide individualized anticoagulant therapy. Methods: From MCCT database of low intensity anticoagulation therapy for Chinese population with heart valve replacement, a total of 236 patients who underwent valve replacement in the Han population were selected as the objects, the demographic factors including age, height, weight, body surface area, body mass index and clinical factors were observed and the correlation was compared between above indexes and warfarin stable dosage followed by obtainment of individual anticoagulation equation. Results: There was no difference in warfarin stable dosage and INR value between the male and the female (p>0.05), atrial fibrillation, pulmonary embolism and heart function were the main influencing factors of warfarin stable dose variation, and there was correlation between the factor of age, height, weight as well as body surface area and stable warfarin stable dose (P<0.05), multivariate linear regression analysis showed that demographic factors could explain 7.1% of warfarin stable dose variation. Conclusion: There is correlation between warfarin stable dosage and demographic factors in patients undergoing valve replacement in Western China and the effects of demographic factors on warfarin should be taken into consideration in the case of warfarin therapy