The preventive effect of cellulose from Pleurotus eryngii on fatty liver of hyperlipidemic rats

Objective: To investigate the preventive effects of Pleurotus eryngii cellulose (PC) on fatty liver rats with hyperlipemia. Methods: Rats were fed with different doses of the cellulose coupled with high fat diet containing cholestyramine as positive control. After 5 weeks, we detect the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC) as well as total triglycerides (TG), and the activities of malonaldehyde (MDA), superoxide dismutase (SOD), hepaticlipase (HL), lipoprteinlipase (LPL) and then we observed the pathological changes in the liver. Results: P. eryngii cellulose could significantly decrease the ALT, AST, TC and TG serum levels (P<0.01), and improve the activity of SOD and HL while significantly inhibit MDA (P<0.05) in a dose dependent manner. In addition, the histopathological test showed that the livers were milk-yellow and bigger in negative group (rats were not treated with cellulose), and there was no fatty generation or vacuoles in the livers in administration group. Conclusion: The preventive effect of the cellulose is similar to the cholestyramine (P<0.05). All results indicated that the cellulose of Pleurotus eryngii has the potential effects on preventing the fatty liver in rats with hyperlipemia