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-  2017 

Optimized Method for the Radiochemical Purity Quality Control of 99mTc-Mertiatide - Nephromag

Keywords: 99mTc-NephroMAG?¢???¢, Analytic method, Radiochemical purity, Radio-thin-layer, Chromatography, list of open access journals, open access, open access journals, open access publication, open access publisher, open access publishing, open access journal articles, imedpub, imedpub publishing, insight medical publishing, imedpub online

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Abstract:

99mTc-NephroMAG? is a radiopharmaceutical which is used for dynamic renal imaging. The summary of product characteristics (SPC) specifies that the determination of radiochemical purity must be achieved via high pressure liquid chromatography or Sep-Pak? C18 cartridge methods. To minimize the time required to test radiochemical purity, a method with radio-thin-layer chromatography (r-TLC) was used in radiopharmacy unit of Tours CHRU. However, this method on Whatman? 3mm was too long and offered no optimized resolving parameters. Methods: For each preparation (n=5), two strips r-TLC with Tec-Control? #150-005 has been achieved, first with hydrophilic mobile phase (hMP) in order to highlight colloidal technetium (99mTcO2), second with lipophilic mobile (lMP) to separate 99mTcO4 Results: The method with two kinds of mobile phase offers a better resolving power for both impurities searched and was more rapid to perform. Conclusion: The simplified method is a reasonable alternative to the registered SPC methods and to the method with Whatman? 3 mm chromatographic paper.

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