Serum adiponectin response to a single heavy cycling in type II diabetic males

Adiponectin is inflammatory peptide hormones that play a key role in glucose metabolism. The objective of this study was to assess the effect of single heavy exercises on adiponectin, insulin sensitivity in type 2 diabetic patients. For this purpose, sixteen type II diabetic men (age, 41 +/- 5 yr, BMI, 34 +/- 3 kg/m2) and none-diabetic men with the matched age with normal weight (BMI, 24 +/- 3 kg/m2) performed a single cycling exercise for 15 minute. Venous blood samples were obtained before and after (immediately) exercise test for measuring serum adiponectin, insulin and glucose. Statistical analysis used by Independent paired T-test. P<0.05 was considered significant. Diabetic patients have lower adiponectin and insulin sensitivity and higher insulin and glucose than none-diabetic subjects (P<0.05). There were no significant changes in all variables in control group by exercise test (P>0.05). In diabetic group, despite serum adiponectin significantly increased and glucose significantly decreased after exercise. But, insulin sensitivity were unchanged (P>0.05). This finding suggested that a single heavy exercise exercises stimulate serum production secretion in type II diabetic patients. But, it appears that adiponectin changes are not associated with insulin sensitivity after this exercise in these patients