Formulation, characterization and evaluation of fluconazole liposomes

The aim of this work was to prepare and evaluate the topical liposomes of Fluconazole. Fluconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were evaluated for in-vitro drug release. The in-vitro diffusion study was carried out by dialysis membrane using both open ended tube. The study was carried out in 40 ml of phosphate buffer solution pH 7.4. The percentage cumulative release from the optimized batch i.e. F7 with drug: lecithin: cholesterol ratio 1: 10: 5, found to be 75.02% release in 8 hours. The magnitude of drug retention within the vesicles on storage under defined conditions ultimately governs shelf life of the developed formulations. Liposomes showed an increasing vesicle size in accelerated temperature but no significance changes at 4 ± 20C has observed in storage studies for two month