Synthesis, Characterization and Antimicrobial Activity Studies of New Amide Derivatives from Benzoyl derivatives of Amino Acid and Selected Sulfa Drugs by Using DCCI

Several compounds which derived from condensation of N-benzoyl-DL-alanine, N-benzoyl glycine, N-benzoyl-Dvaline and N-benzoyl-DL-isoleucine with selected sulfa drugs such as sulfamethoxazole, sulfanilamide, sulfamerazine, sulfamethazine and sulfapyridine by using N,N-dicyclohexyl carbodiimide (DCCI) as an enhancer for the condensation process were synthesis. These compounds that can be considered as amides have been characterized by elemental analysis (C,H,N,S), FT-IR and 1HNMR. The synthesized compounds contain sulfa drug moiety shows excellent antimicrobial activity by using two kinds of bacteria, gram positive Staphylococcus aureus (S. aureus) and gram negative Aeromonas hydrophilic (A. hydrophilia) in different concentration and minimum inhibitory concentration MIC was founded.