Bioadhesive Polymer Buccal Tablets for Losartan Potassium Controlled Delivery: Formulation, In-vitro and Ex-vivo Evaluation

The intention of this research was to develop buccal drug delivery system of Losartan Potassium to enhance the oral bioavailability and prolong the drug release. Carbopol 940P with HPMC (K4M, K15M, K100M), Guar gum, Sodium cmc, Sodium alginate were used as polymers. Tablets were fabricated by direct compression technique and were evaluated for weight variation, thickness, Hardness, Friability, Surface pH, in vitro retention time, mucoadhesive strength, in-vitro drug release & ex-vivo permeation studies. The results of post compressional parameters were within acceptable limits. Amidst all the formulations F9 was tracked down to be the most compatible. The tablets evaluated for various parameters and results are appeased. In-vitro drug release in phosphate buffer (pH 6.8) was found to be 60.25% at the end of 8th hour. The release of Losartan Potassium from the tablet followed Zero order, Higuchi’s model and mechanism diffusion rate limited. Fourier transform infrared results proclaimed that there are no interactions amid Losartan potassium and the polymers used