Synthesis of Pyrimidine 2-ol/thiol Derivatives of Benzimidazole as a Ligand and Their Bi (III) Metal Complexes by Conventional as Well as Microwave Technique

Objectives: The aim of this investigation is a comparative study between traditional (conventional) and microwave technique of metal complexes of Bi (III) with pyrimidine derivatives as a ligand and also determining their antimicrobial activity against selected organisms. Method: Pyrimidine-2-ol/thio derivatives of benzimidazole have been synthesized by 2-acetyl benzimidazole with different aromatic aldehydes and finally the product was cyclised with urea and thiourea to form pyrimidine derivatives of benzimidazoles. In this process we have used both the microwave technique as well as conventional technique. It was observed that the reaction which requires 24-30 hours in conventional method is completed in 25-40 minute by MWI technique. Result: The complexes synthesized through conventional and MWI method were compared in terms of solvent used, time required for synthesis, yield and purity of products. The synthesized ligand and thir metal complexes were characterised through IR, 1HNMR spectroscopy. Coclusion: On the basis of spectrophotometric determination it may be concluded that the metal complexes of Bi (III) appears to acquire the coordination number five and have distorted octahedral geometry. The antimicrobial activity of free pyrimidine ligands and their metal complexes were determined. These activities were compared with the activity of known antibiotics such as Streptomycin and Fluconazole