Design fabrication and characterization of controlled released tablets of Trimetazidine di hydrochloride

The purpose of the present study was to formulate the oral controlled release Trimtazidine di hydrochloride tablets by using HPMC and Xanthan gum as rate controlling polymer. The tablets were prepared by direct compression method. The powder mixtures were evaluated for angle of repose, loose bulk density, tapped bulk density and compressibility index, shows satisfactory results. All the ingredients were lubricated and compressed using 8mm circular shaped deep concave punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness and In-vitro dissolution studies. Drug content in formulation was determined by UV Method. All the formulation showed compliance with Pharmacopoeial standards. The in vitro release study of matrix tablets were carried out in 0.1N Hydrochloric acid with pH 1.2 for 10 hours. Formulation F1, F2, F4 and F5 failed to sustain release beyond 10 hours. Among all the formulation, F3 shows 99.63 % release at the end of 10 hours. It was observed that the amount of polymer influences the drug release. In vitro release study results revealed that the release of drug was retarded with the proportional increase of the polymer concentration