Taste Masking Techniques: Dicyclomine Hydrochloride by Inclusion Complexes with ？2-Cyclodextrin Using Various Oral Formulations

Dicyclomine hydrochloride is anticholinergic drug used as an antispasmodic. It is very bitter in taste. The purpose of this research was to reduce the bitterness of Dicyclomine hydrochloride. Taste masking was done by complexing Dicyclomine hydrochloride with β Cyclodextrin. Drug β- Cyclodextrin complexes were prepared in the ratio 1:1, 1:2 and 1:3 by kneading method. The complexes were characterized by Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) patterns. These studies indicated the inclusion of Dicyclomine in the cavity of β-cyclodextrin. The 1:3 complexation ratio resulted in mask of taste of dicyclomine was selected as it showed acceptable taste and for further use in mouth dissolving oral formulations