Association of Cytochrome P450 with Cancer Induced by Betel Quid (BQ): A Review

Betel quid (BQ) products have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx and others. The human genome encodes fifty-seven cytochrome P45O (P45O, or CYP) proteins. The majority of these are involved in the metabolism of steroids, bile acids, fatty acids and xenobiotic compound which activate carcinogens. The present review focuses on the mechanism of CYP450 with betel quid which induces cancer