Antihyperlipidemic activity of Mangifera indica l. leaf extract on rats fed with high cholesterol diet

Background: Hyperlipidemia is defined as increase in the lipid content in blood. Mangifera indica L., known as mango (Family; Anacardiaceae), commonly used herb in ayurvedic medicine, traditionally used for their antidiabetic, anti-oxidant, anti-viral, cardiotonic, hypotensive, anti-inflammatory properties, antibacterial, anti fungal, anthelmintic, anti parasitic, anti tumor, anti HIV, antibone resorption, antispasmodic, antipyretic, antidiarrhoeal, antiallergic, immunomodulation, hypolipidemic, anti microbial, hepatoprotective, gastroprotective effects. Objective: To investigate effect of aqueous extract of Mangifera indica L.leaf on high cholesterol fed diet rats. Results: High cholesterol fed diet rats exhibited significant increase in total serum cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and significant decrease in high density lipoproteins. Treatment with aqueous extract of Mangifera indica leaves significantly decreased total serum cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and increased in high density lipoproteins rats. Conclusion: Hypolipidemic activity of M. indica may be attributed due to presence of flavonoids, Saponins, glycosides, tannins, phenolics