Impact of Particles Size on Solubility Limits and 3D-AFM-Nano-Structural Features of Cefixime Drug

Objective: The present investigations are focusing to give informative data on the effect of particles size on the solubility limits of cefixime antibiotic. Methods: 3D-AFM, SEM and XRD will be applied to monitoring the effect of grain size on solubility limits and to introduce complete image with analysis for micro-structural features of cefixime drug. Results: Solubility of cefixime drug was grain size dependent and 3D-AFM features of cefixime play important role in solubility limits besides solvent type .Obtained results confirmed that, there are strong correlation between surface area and solubility limits of cefixime. Conclusion: Hyperfine nano-structural features for cefixime have vital role in its solubility limits and answer the question why this hetero-molecule is suitable structurally to their function as antibacterial drug