Tonsillectomy among children with low baseline acute throat infection consultation rates in UK general practices: a cohort study

Objective To investigate the effectiveness of tonsillectomy in reducing acute throat infection (ATI) consultation rates over 6？years’ follow-up among children with low baseline ATI consultation rates. Design Retrospective cohort study. Setting UK general practices from the Clinical Practice Research Datalink. Participants Children aged 4–15？years with ≤3 ATI consultations during the 3？years prior to 2001 (baseline). 450 children who underwent tonsillectomy (tonsillectomy group) and 13？442 other children with an ATI consultation (comparison group) in 2001. Main outcome measures Mean differences in ATI consultation rates over the first 3？years’ and subsequent 3？years’ follow-up compared with 3？years prior to 2001 (baseline); odds of ≥3 ATI consultations at the same time points. Results Among children in the tonsillectomy group, the 3-year mean ATI consultation rate decreased from 1.31 to 0.66 over the first 3？years’ follow-up and further declined to 0.60 over the subsequent 3？years’ follow-up period. Compared with children who had no operation, those who underwent tonsillectomy experienced a reduction in 3-year mean ATI consultations per child of 2.5 (95% CI 2.3 to 2.6, p<0.001) over the first 3？years’ follow-up, but only 1.2 (95% CI 1.0 to 1.4, p<0.001) over the subsequent 3？years’ follow-up compared with baseline, respectively. This equates to a mean reduction of 3.7 ATI consultations over a 6-year period and approximates to a mean annual reduction of 0.6 ATI consultations per child, per year, over 6？years’ follow-up. Children who underwent tonsillectomy were also much less likely to experience ≥3 ATI consultations during the first 3？years’ follow-up (adjusted OR=0.12, 95% CI 0.08 to 0.17) and the subsequent 3？years’ follow-up (adjusted OR=0.24, 95% CI 0.14 to 0.41). Conclusions Among children with low baseline ATI rates, there was a statistically significant reduction in ATI consultation rates over 6？years’ follow-up. However, the relatively modest clinical benefit needs to be weighed against the potential risks and complications associated with surgery