Due to poverty and ignorance more than half of the pregnant women in developing country are suffering from iron deficiency anaemia (IDA). Different gastrointestinal side effects cause low compliance to iron supplementation. Amloki (Emblica officinalis) is very popular among pregnant women for its taste and traditional belief of well-being. The aim of this study is to determine the effects of amloki on RBC, WBC and Platelet count. Prospective comparative study was carried out on patients of Outpatient Department of Obstetrics and Gynecology, Dhaka Medical College Hospital from July 2016 to June 2017. A total of 43 pregnant women between the 13th to the 20th weeks of gestation with IDA were selected aged 18 - 36 years in this study. Anemic pregnant women supplemented with oral iron and amloki were considered as study group (A) and control group (B) were with only iron supplementation for 45 days. Total count of RBC, WBC and platelet were done in the Department of Hematology & BMT Unit, Dhaka Medical College Hospital, Dhaka. For statistical analysis, Paired Student’s “t” test and Unpaired Student’s “t” test were considered using SPSS 22.0 version. A significant increase (p < 0.05) of blood RBC count was observed after intervention of iron in both groups. There was also significant increase in RBC count in iron + amloki supplemented group than that of only iron supplemented group. In this study, there was also increase of WBC count in iron + amloki supplemented group and decrease of platelet count in both groups, but these changes were not statistically significant. It can be concluded that oral amloki supplementation causes increased blood RBC count in IDA with pregnancy.
References
[1]
Rupara, A.V., Donga, S.B. and Dei, L. (2013) A Comparative Study on the Effect of Pandughnivati and Dhatrilauhavati in the Management of Garbhinipandu (Iron Deficiency Anemia). Ayu, 34, 276-280. https://doi.org/10.4103/0974-8520.123120
[2]
Huda, N.M., Mishra, D.S. and Singh, J.P. (2014) Clinical Evaluation of an Ayurvedic Preparation for the Treatment of Iron Deficiency Anemia in Patients. Journal of Homeopathy & Ayurvedic Medicine, 3, 162.
[3]
Idoate Gastearena, M.A., Gil, A.G., Azqueta, A., Coronel, M.P. and Gimeno, M. (2003) A Comparative Study on the Gastroduodenal Tolerance of Different Antianaemic Preparations. Human & Experimental Toxicology, 22, 137-141. https://doi.org/10.1191/0960327103ht330oa
[4]
Benjwal, S. (2013) Role of Amalaki (Emblica officinalis) Churna in Iron Deficiency Anemia in Pregnant Women. Ayurpharm International Journal of Ayurveda and Allied Sciences, 2, 48-51.
[5]
Khandelwal, D.A., Donga, S.B. and Dei, L. (2015) Clinical Efficacy of Punarva Mandura and Dhatrilauha in the Management of Garbhini Pandu (Anemia in Pregnancy). Ayu, 36, 397-403. https://doi.org/10.4103/0974-8520.190700
[6]
Khot, B.M., Patil, A.J. and Kakad, A.C. (2013) Comparative Clinical Study of Dhatri Lauha and Navayasa Lauha in Garbhini Panduroga with Reference to Anemia in Pregnancy. IOSR Journal of Dental and Medical Sciences, 11, 28-33. https://doi.org/10.9790/0853-1112833
[7]
Terri, D., Wimbley, J. and Graham, D.Y. (2011) Diagnosis and Management of Iron Deficiency Anaemia in the 21st Century. Therapeutic Advances in Gastroenterology, 4, 177-184. https://doi.org/10.1177/1756283X11398736
[8]
Harper, J.L. (2020) Iron Deficiency Anemia Workup [Internet]. Web Med., New York. http:///emedicine.medscape.com/article/202333-workup
[9]
Klemn, R.D.W., Sommerfelt, A.E., Boyo, A., Barba, C., Kotecha, P., Steffen, M. and Franklin, N. (2011) Are We Making Progress on Reducing Anemia in Women? United States Agency for International Development, Washington DC. http://www.a2zproject.org/pdf/ReducingAnemia_low_res_06212011.pdf
[10]
Sharma, R., Jain, N., Rani, D., Jaitawat, A. and Kantawa, S.M. (2015) Role of Emblica officinalis and Foeiniculum vulgare during Pregnancy and Lactation. International Journal of Advanced Multidisciplinary Research, 2, 103-113.
[11]
Sana, H. and Sinha, M.P. (2015) Effect of Emblica officinalis Fruit Extracts on Haematological Profile and Serum Lipid Variables of Albino Rats. Global Journal of Pharmacology, 9, 311-315.
[12]
Dasaroju, S. and Gottumukkala, K.M. (2014) Current Trends in the Research of Emblica officinalis (Amla): A Pharmacological Perspective. International Journal of Pharmaceutical Sciences Review and Research, 24, 150-159.
[13]
Scartezzini, P., Antognoni, F., Raggi, M.A., Poli, F. and Sabbioni, C. (2005) Vitamin C Content and Antioxidant Activity of the Fruit and of the Ayurvedic Preparation of Emblica officinalis Gaertn. Journal of Ethnopharmacology, 104, 113-118. https://doi.org/10.1016/j.jep.2005.08.065
[14]
Venkatasubramanian, P., Koul, I.B., Varghese, R.K., Koyala, S. and Shivakumar, A. (2014) Amla Enhances Iron Dialysability and Uptake in In-Vitro Models. Current Science, 107, 1859-1864.
[15]
Sharp, P. and Srai, S.K. (2007) Molecular Mechanisms Involved in Intestinal Iron Absorption. World Journal of Gastroenterology, 13, 4716-4724. https://doi.org/10.3748/wjg.v13.i35.4716
[16]
Layeeq, S. and Thakar, A.B. (2015) Clinical Efficacy of Amloki Rasayana in the Management of Pandu (Iron Deficiency Anemia). Ayu, 36, 290-297. https://doi.org/10.4103/0974-8520.182761
[17]
Roy, A. and Dwivedi, M. (2014) Dhatrilauha: Right Choice for Iron Deficiency Anemia in Pregnancy. Ayu, 35, 283-288. https://doi.org/10.4103/0974-8520.153745
[18]
Joshi, N., Dash, M.K., Dwivedi, L.K. and Khilani, G.D. (2015) Clinical Evaluation of Ayurvedic Iron (Lauha) Containing Preparations in Iron Deficiency Anaemia. International Journal of Research in Ayurveda and Pharmacy, 6, 225-231. https://doi.org/10.7897/2277-4343.06246
[19]
Ramadevi, G., Jonah, S. and Prasad, U.N. (2014) A Clinical Study on the Effect of Dhatri Lauha in Garbhinipandu (Iron Deficiency Anaemia). International Journal of Research in Ayurveda and Pharmacy, 5, 708-712. https://doi.org/10.7897/2277-4343.056143
[20]
Allen, L.H. and Ahluwalia, N. (1997) Improving Iron Status through Diet. In: Wagner, L.V., Ed., Relative Impact of Potential Interventions to Improve Dietary Iron Availability, Opportunities for Micronutrients Intervention, Washington DC, 1-86.
[21]
Yadav, V., Duvey, B., Sharma, S. and Devi, B. (2014) Amla (Emblica officinalis) Medicinal Food and Pharmacological Activity. International Journal of Chemical and Pharmaceutical Sciences, 3, 616-619.
[22]
Okot-Asi, T.N.E., Chinaka, N.O., Ofem, O.E., et al. (2015) Effect of Moringa oleifera Lam. Ethanol Leaf Extract on Hematology in Phenyl Hydrazine Induced Anemic Albino Wister Rats. American Journal of Pharmacological Sciences, 3, 67-73.
[23]
Kadikoylu, G., Yavasoglu, I., Bolaman, Z. and Senturk, T. (2006) Platelet Parameters in Women with Iron Deficiency Anemia. Journal of the National Medical Association, 98, 398-402.
[24]
Roy, A.K.D., Gordon, M.J. and William, B.C. (1999) Inhibitory Effect of Ginco Biloba Extracts on Human Platelet Aggregation. Platelets, 10, 298-305. https://doi.org/10.1080/09537109975933
[25]
Adebayo, A.H., Abolaji, A.O., Opata, T.K. and Adekbenro, I.K. (2010) Effects of Ethanolic Leaf Extract of Chrysophyllum albidum G. on Biochemical and Haematological Parameters of Albino Wister Rats. African Journal of Biotechnology, 9, 2145-2150.