全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

纳米氧化锌的体内分布以及安全性研究进展
Research Progress on Vivo Distribution and Safety of Nano-Sized Zinc Oxide

DOI: 10.12677/AAC.2020.104016, PP. 107-114

Keywords: 纳米氧化锌，体内过程，毒性效应，研究进展
ZnO NPs, Vivo Process, Toxic Effect, Research Progress

Full-Text   Cite this paper   Add to My Lib

Abstract:

随着纳米技术领域的迅速发展，纳米材料的消费产品及其工业应用也不断增加，目前，纳米产品已经被广泛应用于诊断、食品、化妆品、油漆等领域。其中，由于纳米氧化锌具有良好的抗菌、抗紫外线、耐热以及除臭等特性，它已经被广泛应用于农业、抗癌药物的生产以及食品包装材料。正是由于纳米氧化锌在这些领域中的应用，增加了氧化锌暴露于机体的机会。本文综述了纳米氧化锌经过各种途径作用于机体后的吸收、分布、代谢和排泄等体内过程，并介绍了纳米氧化锌的毒性效应。以期为纳米氧化锌的研究与应用提供参考。
With the rapid promotion of nanotechnology, the application of nanomaterials in consumer products and industrial has been increased as well. Nowadays, nanomaterials have been widely applied in areas involving diagnosis, food, cosmetics, paint and so forth. Due to the excellent property of ZnO NPs, such as good antibacterial, anti-ultraviolet, heat resistance and deodorization, it has been extensively exerted in agriculture, the production of anticancer drugs and food packaging materials. However, it is the common application of ZnO NPs in these fields that has increased the risk of human being exposed to ZnO NPs. Therefore, this paper reviewed not only the process of absorption, distribution, metabolism and excretion, but also the toxic effects after exposing ZnO NPs to the all kinds of experimental animals in various ways. It is our expectation that this article could provide reference for the future research and application of ZnO NPs.

References

[1]  Cock-a-doodle-doo, A., Stebounova, L.V., Kim, J.S., et al. (2014) Toxicity Assessment of Zinc Oxide Nanoparticles Using Sub-Acute and Sub-Chronic Murine Inhalation Models. Particle and Fibre Toxicology, 11, 15.
https://doi.org/10.1186/1743-8977-11-15
[2]  Liu, J., Feng, X., Wei, L., Chen, L., Song, B. and Shao, L. (2016) The Toxicology of Ion-Shedding Zinc Oxide Nanoparticles. Critical Reviews in Toxicology, 46, 348-384.
https://doi.org/10.3109/10408444.2015.1137864
[3]  Du, J., Tang, J., Xu, S., et al. (2020) ZnO Nanoparticles: Recent Advances in Ecotoxicity and Risk Assessment. Drug and Chemical Toxicology, 43, 322-333.
https://doi.org/10.1080/01480545.2018.1508218
[4]  Yang, P., Hong, W., Zhou, P., et al. (2017) Nano and Bulk ZnO Trigger Diverse Zn-Transport-Related Gene Transcription in Distinct Regions of the Small Intestine in Mice after Oral Exposure. Biochemical and Biophysical Research Communications, 493, 1364-1369.
https://doi.org/10.1016/j.bbrc.2017.09.165
[5]  洪丽玲, 张天宝. 3种粒径纳米氧化锌与常规氧化锌对大鼠的亚慢性毒性[J]. 癌变·畸变·突变, 2018, 30(1): 52-57.
[6]  Jo, E., Seo, G., Kwon, J.T., et al. (2013) Exposure to Zinc Oxide Nanoparticles Affects Reproductive Development and Biodistribution in Offspring Rats. The Journal of Toxicological Sciences, 38, 525-530.
https://doi.org/10.2131/jts.38.525
[7]  张金洋. 纳米氧化锌和二氧化钛的毒性效应及致毒机制探讨[D]: [硕士学位论文]. 上海: 上海交通大学环境工程, 2012.
[8]  Choi, S., Baek, M., Chung, H., et al. (2012) Pharmacokinetics, Tissue Distribution, and Excretion of Zinc Oxide Nanoparticles. International Journal of Nanomedicine, 7, 3081-3097.
https://doi.org/10.2147/IJN.S32593
[9]  杜利静. 经口摄入纳米氧化锌在小鼠中的分布和毒性[D]: [硕士学位论文]. 上海: 上海大学, 2014.
[10]  Wang, C., Lu, J., Zhou, L., et al. (2016) Effects of Long-Term Exposure to Zinc Oxide Nanoparticles on Development, Zinc Metabolism and Biodistribution of Minerals (Zn, Fe, Cu, Mn) in Mice. PLoS ONE, 11, e164434.
https://doi.org/10.1371/journal.pone.0164434
[11]  Annangi, B., Annangi, B., Rubio, L., et al. (2016) Acute and Long-Term in Vitro Effects of Zinc Oxide Nanoparticles. Archives of Toxicology, 90, 2201-2213.
https://doi.org/10.1007/s00204-015-1613-7
[12]  Zhao, X., Wang, S., Wu, Y., et al. (2013) Acute ZnO Nanoparticles Exposure Induces Developmental Toxicity, Oxidative Stress and DNA Damage in Embryo-Larval Zebrafish. Aquatic Toxicology, 136-137, 49-59.
https://doi.org/10.1016/j.aquatox.2013.03.019
[13]  Ickrath, P., Wagner, M., Scherzad, A., et al. (2017) Time-Dependent Toxic and Genotoxic Effects of Zinc Oxide Nanoparticles after Long-Term and Repetitive Exposure to Human Mesenchymal Stem Cells. International Journal of Environmental Research and Public Health, 14, 1590.
https://doi.org/10.3390/ijerph14121590
[14]  Okada, Y., Tachibana, K., Yanagita, S., et al. (2013) Prenatal Exposure to Zinc Oxide Particles Alters Monoaminergic Neurotransmitter Levels in the Brain of Mouse Offspring. The Journal of Toxicological Sciences, 38, 363-370.
https://doi.org/10.2131/jts.38.363
[15]  王群林, 李岩, 许聪, 等. 纳米ZnO对小鼠肺的毒性效应[J]. 安徽农业科学, 2014, 42(31): 10976-10978.
[16]  Landsiedel, R., Ma-Hock, L., Hofmann, T., et al. (2014) Application of Short-Term Inhalation Studies to Assess the Inhalation Toxicity of Nanomaterials. Particle and Fibre Toxicology, 11, Article No. 16.
https://doi.org/10.1186/1743-8977-11-16
[17]  梁宁. 纳米氧化锌对大鼠的心血管毒性作用[D]: [硕士学位论文]. 郑州: 郑州大学劳动卫生与环境卫生学, 2012.
[18]  Bessemer, R.A., Butler, K.M.A., Tunnah, L., et al. (2015) Cardiorespiratory Toxicity of Environmentally Relevant Zinc Oxide Nanoparticles in the Freshwater Fish Catostomus commersonii. Nanotoxicology, 9, 861-870.
https://doi.org/10.3109/17435390.2014.982737
[19]  Pasupuleti, S., Alapati, S., Ganapathy, S., et al. (2011) Toxicity of Zinc Oxide Nanoparticles through Oral Route. Toxicology and Industrial Health, 28, 675-686.
https://doi.org/10.1177/0748233711420473
[20]  Gao, L., Yang, S.T., Li, S., et al. (2013) Acute Toxicity of Zinc Oxide Nanoparticles to the Rat Olfactory System after Intranasal Instillation. Journal of Applied Toxicology, 33, 1079-1088.
https://doi.org/10.1002/jat.2842
[21]  Yang, X., Shao, H., Liu, W., et al. (2015) Endoplasmic Reticulum Stress and Oxidative Stress Are Involved in ZnO Nanoparticle-Induced Hepatotoxicity. Toxicology Letters, 234, 40-49.
https://doi.org/10.1016/j.toxlet.2015.02.004
[22]  Samei, M., Sarrafzadeh, M. and Faramarzi, M.A. (2019) The Impact of Morphology and Size of Zinc Oxide Nanoparticles on Its Toxicity to the Freshwater Microalga, Raphidocelis subcapitata. Environmental Science and Pollution Research, 26, 2409-2420.
https://doi.org/10.1007/s11356-018-3787-z
[23]  何星平, 杨鹏飞, 况慧娟, 许恒毅. 纳米氧化锌在食品领域中的应用及安全性研究进展[J]. 食品安全质量检测学报, 2016, 7(11): 4525-4530.
[24]  孔子浩, 王振宇, 陈妮, 周阿容, 曾绍校, 林少玲. 纳米氧化锌在食品中的应用及毒理学研究进展[J]. 保鲜与加工, 2019, 19(2): 174-178.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133