中药免疫调节作用及临床应用的研究进展
Progress of Immunomodulatory Effect and Clinical Application of Traditional Chinese Medicine

DOI: 10.12677/PI.2020.96029, PP. 197-203

Keywords: 中药，免疫调节，应用，研究进展
Traditional Chinese Medicine, Immune Regulation, Application, Research Progress

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Abstract:

免疫功能紊乱与许多疾病的发病有着重要相关性。由于中药在免疫调节过程中疗效显著，具有毒副作用小，多靶点全程施效，不易产生耐药性等诸多优势，应用前景广阔，成为当下的研究热点。本文对部分中药的免疫调节作用及其临床应用进行归纳总结，并立足现状进行前景展望。以期为中药的免疫调节作用研究提供借鉴，为进一步发掘中药的潜在应用价值提供新思路。
Immune dysfunction is closely related to many diseases. Tradition Chinese medicine presents significant curative effect in the process of immune regulation with advantages of little side-effects, multi-target, and little drug-resistant; therefore, it possesses a wide application prospect, and has become a research hotspot at present. This article reviewed the immunomodulatory effects of some traditional Chinese medicines and their clinical applications, and evaluated the future prospects based on the current situation prospects. We hope to provide reference for the study of immune regulation of traditional Chinese medicine and provide proposed new ideas for further exploring the potential application value of traditional Chinese medicine.

References

[1]	Zhang, R.P., Zhang, X.P., Ruan, Y.F., et al. (2009) Protective Effect of Radix Astragali Injection on Immune Organs of Rats with Obstructive Jaundice and Its Mechanism. World Journal of Gastroenterology, 15, 2862-2869. https://doi.org/10.3748/wjg.15.2862
[2]	隋明静. 植物提取复方制剂对断奶仔猪生长性能、免疫机能及肠道菌群的影响[D]: [硕士学位论文]. 保定: 河北农业大学, 2019.
[3]	Han, R., Wu, W.Q., Wu, X.P., et al. (2015) Ef-fect of Total Flavonoids from the Seeds of Astragali complanati on Natural Killer Cell Function. Journal of Ethnophar-macology, 173, 157-165. https://doi.org/10.1016/j.jep.2015.07.017
[4]	陈伟, 马小琴, 范文玺, 等. 红景天主要成分对小鼠免疫细胞的促增殖转化作用[J]. 中国现代应用药学, 2016, 33(1): 38.
[5]	Li, H.Q., Xu, S.M., Cheng, T.T., et al. (2015) Effects of Traditional Chinese Medicine Fu Zheng Decoction on the Immunological Function and Clinical Prognosis of the Elderly Patients with Pneumonia. Cell Biochemistry and Biophysics, 71, 473. https://doi.org/10.1007/s12013-014-0227-7
[6]	Yuan, Q.Y., Zhang, X.N., Liu, Z.W., et al. (2013) Ethanol Extract of Adiantum capillus-veneris L. Suppresses the Production of Inflammatory Mediators by Inhibiting NF-κB Activation. Journal of Ethnopharmacology, 147, 603-611. https://doi.org/10.1016/j.jep.2013.03.046
[7]	李覃, 陈虹, 梅昕, 等. 青蒿素的免疫抑制作用及其调控机制研究[J]. 中国药理学通报, 2011, 27(6): 848.
[8]	Wang, J., Lu, J.L., Lan, Y., et al. (2013) Total Coumarins from Urtica dentata Hand Prevent Murine Autoimmune Diabetes via Suppression of the TLR4-Signaling Pathways. Journal of Eth-nopharmacology, 146, 379. https://doi.org/10.1016/j.jep.2013.01.009
[9]	于小迪, 王为忠, 焦婕英, 等. 青蒿琥酯对大鼠小肠移植急性排斥反应的作用[J]. 中国组织工程研究, 2014, 18(5): 761-766.
[10]	李玉卿, 朱月春, 赵文娟, 等. 三七总皂苷免疫调节作用研究进展[J]. 云南中医中药杂志, 2015, 36(6): 96-98.
[11]	Lemmom, H.R., Sham, J., Chau, L.A., et al. (2012) High Molecular Weight Polysaccharides Are Key Immunomodulators in North American Ginseng Extracts: Characterization of the Ginseng Genetic Signature in Primary Human Immune Cells. Journal of Ethnopharmacology, 142, 1-13. https://doi.org/10.1016/j.jep.2012.04.004
[12]	Jordan, J.L., Nowak, A. and Lee, T.D. (2010) Activation of Innate Immunity to Reduce Lung Metastases in Breast Cancer. Cancer Immunology, Immunotherapy, 59, 789-797. https://doi.org/10.1007/s00262-009-0800-x
[13]	Nakada, T., Watanabe, K., Jin, G.B., et al. (2002) Effect of Nin-jin-Youei-To on Th1/Th2 Type Cytokine Production in Different Mouse Strains. The American Journal of Chinese Medicine, 30, 215. https://doi.org/10.1142/S0192415X0200034X
[14]	陈秋莹, 詹剑华. 中药免疫调节作用及其研究进展[J]. 江西医药, 2019, 54(2): 181-184.
[15]	Lai, X.Y., Xia, W.B., Wei, J., et al. (2017) Therapeutic Effect of Astragalus Poly-saccharides on Hepatocellular Carcinoma H22-Bearing Mice. Dose-Response, 15, 3517-3524. https://doi.org/10.1177/1559325816685182
[16]	Zheng, Y.S., Wu, Z.S., Ni, H.B., et al. (2014) Codonopsis plosula Polysaccharide Attenuates Cecal Ligation and Puncture Sepsis via Circuiting Regulatory T Cells in Mice. Shock, 41, 250. https://doi.org/10.1097/SHK.0000000000000091
[17]	周悦芳, 范培红. 中药免疫调节作用研究进展[J]. 时珍国医国药, 2017, 28(1): 204-207.
[18]	杨逸, 覃筱燕, 郭哲, 等. 人参皂苷Rg1对小鼠免疫性肝损伤保护作用[J]. 中国公共卫生, 2015, 31(3): 309.
[19]	林碧霞. 金线莲挥发油成分的提取及体外免疫活性研究[D]: [硕士学位论文]. 福州: 福建医科大学, 2017.
[20]	Xu, Y.K., Liao, S.G., Na, Z., et al. (2012) Gelsemium Alkaloids, Immunosup-pressive Agents from Gelsemium elegans. Fitoterapia, 83, 1120. https://doi.org/10.1016/j.fitote.2012.04.023
[21]	季晓, 宣槐斌, 黄宝康. 明党参活性成分及药理作用研究进展[J]. 药学实践杂志, 2015, 33(2): 102-105, 137.
[22]	Quan, F.S., Compans, R.W., Cho, Y.K., et al. (2006) Ginseng and Salviae Herbs Play a Role as Immune Ac-tivators and Modulate Immune Responses during Influenza Virus Infection. Vaccine, 25, 272-282. https://doi.org/10.1016/j.vaccine.2006.07.041
[23]	李钦, 胡继宏, 高博, 等. 黄芪多糖在免疫调节方面的最新研究进展[J]. 中国实验方剂学杂志, 2017, 23(2): 199-206.
[24]	高玲, 杨茜, 黄英, 等. 基于细胞因子风暴理论探讨中药在病毒性肺炎中的应用[J]. 中药药理与临床, 2020, 36(2): 19-25.
[25]	余亚茹, 鲁鹏飞, 王红霞, 等. 中药防治新型冠状病毒肺炎概述[J]. 药学实践杂志, 2020, 38(3): 202-206+210.
[26]	Chen, L.J., Yan, X., Yan, Q.L., et al. (2015) The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine, 2015, Article ID: 790739. https://doi.org/10.1155/2015/790739
[27]	Zhu, H.Y., Huang, H., Shi, X.L., et al. (2015) Qiangzhi Decoc-tionprotects Mice from Influenza A Pneumonia through Inhibition of Inflammatory Cytokine Storm. Chinese Journal of Integrative Medicine, 21, 376-383. https://doi.org/10.1007/s11655-014-2020-2
[28]	王爱帅, 刘雨晴, 蒋珊, 等. 中医药调控免疫检查点治疗恶性肿瘤研究进展[J]. 江苏中医药, 2020, 52(5): 86-89.
[29]	陈燕妮, 王兰兰, 查青, 等. 中医药在肿瘤免疫治疗方面的研究进展[J]. 辽宁中医杂志, 2020, 47(4): 201-203.
[30]	Sun, M.Y., Ye, Y., Xiao, L., et al. (2017) Anticancer Ef-fects of Ginsenoside Rg3 (Review). International Journal of Molecular Medicine, 39, 507. https://doi.org/10.3892/ijmm.2017.2857
[31]	Shao, Y.Q., Zhu, W.J., Da, J., et al. (2017) Bisdemethoxycurcumin in Combination with α-PD-L1 Antibody Boosts Immune Response against Bladder Cancer. OncoTargets and Therapy, 10, 2675. https://doi.org/10.2147/OTT.S130653
[32]	瞿小玲, 曾仪, 姚利. 黄芪甲苷下调PD-1及PD-L1的表达对宫颈癌Hela细胞侵袭和迁移的抑制作用[J]. 免疫学杂志, 2018, 34(10): 850.
[33]	林颖, 邓宇琳, 王菊勇. 补肾益肺解毒法对Lewis肺癌小鼠CD4~+CD25~+调节性T细胞、Foxp3及B7-H3的影响[J]. 河南中医, 2017, 37(11): 1911.
[34]	Mao, G.H., Zhang, Z.H., Fei, F., et al. (2019) Effect of Grifola frondosa Polysaccharide on Anti-Tumor Ac-tivity in Combination with 5-Fu in Heps-Bearing Mice. International Journal of Biological Macromolecules, 121, 930-935. https://doi.org/10.1016/j.ijbiomac.2018.10.073
[35]	崔崎, 郭小鹏, 成俊, 等. 香菇多糖与环磷酰胺联合治疗前列腺癌荷瘤小鼠的实验研究[J]. 中华肿瘤防治杂志, 2017, 24(14): 971-975.
[36]	王进, 陈涛. 中药调节免疫治疗白癜风研究进展[J]. 实用医院临床杂志, 2020, 17(2): 248-251.
[37]	Li, Z.J., He, X., Liu, F., et al. (2018) A Review of Polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, Functions and Applications. Carbohydrate Polymers, 184, 178-190. https://doi.org/10.1016/j.carbpol.2017.12.058
[38]	韦刚. 中药内服加外用治疗白癜风新突破[J]. 世界最新医学信息文摘, 2018, 18(71): 131.
[39]	张瑾, 李铁男, 刘文力, 等. 抗酪氨酸酶抗体和抗酪氨酸酶相关蛋白-1抗体检测与快速进展期白癜风疗效的相关性分析[J]. 中国中西医结合皮肤性病学杂志, 2018, 17(6): 493-496.
[40]	张翠. 苦参素胶囊联合窄谱中波紫外线对白癜风患者血清IL-6，IL-8及IL-17的影响[J]. 现代中西医结合杂志, 2018, 27(6): 654-656.
[41]	金星漂, 王钰乐, 贺爽, 等. 炎症免疫调节作为活血化瘀中药防治深静脉血栓新策略的探讨[J]. 中草药, 2019, 50(11): 2718-2727.

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