原发性肝癌是一种常见的肝脏恶性肿瘤，发病率和死亡率较高，且由于早期难以被诊断，以致于错失有效治疗机会。环状RNA (circRNA)是内源性长链非编码RNA家族中的一员，因其具有稳定性，高度保守性和时间、空间特异性等特征，故其广泛累积表达于真核细胞的细胞质中。近年来发现circRNA在原发性肝癌的细胞增殖、凋亡、侵袭转移及预后等多方面发挥着巨大作用。目前circRNA已是继LncRNA后作为多种肿瘤早期诊断标志物和新治疗靶点的研究热点。本文对circRNA特征及其在原发性肝癌中的相关研究进展进行概述，以便于进一步探究其在原发性肝癌的临床诊疗过程中的潜在应用。
Primary liver cancer is a common malignant liver tumor with high incidence rate and mortality rate. It is difficult to be diagnosed during its early stage, which leads to missed effective treatment. Circular RNA (circRNA) is a member of the endogenous long-chain noncoding RNA family. It is widely accumulated in the cytoplasm of eukaryotic cells because of its stability, high conservation, time and space specificity. In recent years, it has been found that circRNA plays an important role in proliferation, apoptosis, invasion, metastasis and prognosis of primary liver cancer. At present, after lncRNA, circRNA has become a research hotspot as a variety of tumor early diagnostic markers and new therapeutic targets. This paper aims to summarize the characteristics of circRNA and its related research progress in primary liver cancer, so as to further explore its potential application in the clinical diagnosis and treatment of primary liver cancer.
