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缺氧诱导因子-2在头颈部肿瘤中的研究进展
Research Progress of Hypoxia Inducible Factor-2 in Head and Neck Tumors

DOI: 10.12677/ACM.2020.1010357, PP. 2367-2371

Keywords: 缺氧诱导因子-2，头颈部肿瘤，恶性肿瘤
Hypoxia Inducible Factor-2, Head and Neck Tumors, Malignant Tumors

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Abstract:

缺氧诱导因子-2 (Hypoxia Inducible Factor-2, HIF-2)作为缺氧诱导因子家族中的一员，与多种恶性肿瘤发生发展密切相关。头颈部肿瘤是一组包括鼻咽癌、喉癌、口腔癌、甲状腺癌等临床常见的恶性肿瘤，具有高死亡率及高致残率的特点。近年来研究表明HIF-2与头颈部肿瘤关系密切。本文就HIF-2的结构、调控及其与头颈部肿瘤进展的关系作一综述。
Hypoxia inducible factor-2 (HIF-2), as a member of the hypoxia inducible factor family, is closely related to the occurrence and development of various malignant tumors. Head and neck cancer are a group of clinical common malignant tumors, including nasopharyngeal carcinoma, laryngeal cancer, oral cancer, thyroid cancer and so on. Recent studies have shown that HIF-2 is closely related to head and neck tumors. This article reviews the structure and regulation of HIF-2 and its relationship with the progression of head and neck tumors.

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