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椎间盘退变信号通路的研究进展
Research Progress of the Signal Pathway of Intervertebral Disc Degeneration

DOI: 10.12677/ACM.2020.1010351, PP. 2329-2336

Keywords: 椎间盘，退变，信号通路
Intervertebral Disc, Degeneration, Signaling Pathway

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Abstract:

椎间盘退变是引起腰痛的诸多要素中的主要因素之一，其退变是一个细胞分子损伤长时间积累的过程，该过程破坏了组织细胞内的稳态，最终造成生理功能的衰退。椎间盘退变的机制还未被完全阐明。在椎间盘退变的过程中，信号通路发挥着十分重要的作用，其中包括MAPK、Wnt/β-catenin、NF-κB、Notch、PI3K/Akt等多种信号通路的改变，这些信号通路又相互交叉作用形成了一个错综复杂的信号通路网络，共同参与椎间盘退变的调控。随着对细胞信号通路研究的深入，椎间盘退变的原因将进一步被阐明，同时为其临床治疗提供新的思路。现将最近几年来椎间盘退变信号通路的研究进展综述如下。
Intervertebral disc degeneration is one of the main factors that cause low back pain. Its degeneration is a process of long-term accumulation of cellular and molecular damage, which destroys the homeostasis of tissue cells and ultimately leads to the decline of physiological functions. The mechanism of disc degeneration has not been fully elucidated. In the process of intervertebral disc degeneration, signal pathways play a very important role, including changes in many signal pathways such as MAPK, Wnt/β-catenin, NF-κB, Notch, PI3K/Akt, and these signal pathways cross each other. The role forms an intricate network of signaling pathways, which jointly participate in the regulation of intervertebral disc degeneration. With the in-depth research on cell signaling pathways, the causes of intervertebral disc degeneration will be further clarified, and at the same time provide new ideas for its clinical treatment. The research progress of intervertebral disc degeneration signaling pathway in recent years is summarized as follows.

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