The Synthesis and Hybridization Studies of Oligodeoxyribonucleotides Containing the 2'-Deoxyguanosine Modification, 8-Aza-3-deaza-2'-deoxyguanosine

Sa？etak Chemical and physical properties of the modified nucleoside 8-aza-3-deaza-2’-deoxyguanosine (1) are described. From the amino protected nucleoside 1a, phosphoramidite 3 was prepared, and oligo-deoxyribonucleotides were synthesized. Duplexes containing compound 1 are slightly less stable than the natural duplex