A Physico-chemical Study of the Interaction of Cobalt(II) Ion with Ciprofloxacin

Sa？etak Reaction between the quinolone antibacterial agent Ciprofloxacin (abbreviation cfH) and Co11 in aqueous medium was studied. The ability of Ciprofloxacin to form metal complexes is highly dependent on the pH value of the solution. UV spectroscopy and solubility of Ciprofloxacin ？ HC1 were used to determine the optimal conditions for complex isolation in the pH region between 5 and 10, where the solubility of quinolones is very low. The isolated complex [Co(cf)2]× 3H20 was characterized by elemental analysis, FAB-MS, TG analysis, IR spectroscopy and magnetic measurements. Cobalt K-edge EXAFS was used for the Identification of the Co site in the complex