2-Oxaadamantane-1-N,N,N-trimethylmethanaminium Iodide: Synthesis and Potential for Muscarinic Activity

Sa？etak The synthesis of the title compound from adamantanone is described. The series of steps include ring expansion and hydrolysis to endo-7-hydroxy-exo-3-bicyclo(3.3.1)nonane carboxylic acid, followed by oxidative ring closure using lead tetraacetate. The final, substituted oxaadamantane incorporates the key functional group elements known to be necessary for useful muscarinic activity into a molecular geometry not present in acetylcholine agonists or antagonists previously prepared