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-  2018 

Block relevance (BR) analysis and polarity descriptors in property-based drug design

DOI: 10.5599/admet.532

Keywords: ADME, hydrogen bonding, IAM, QSPR, PLS, PSA, VIP

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Abstract:

Sa?etak Block Relevance (BR) analysis is a tool to interpret QSPR/PLS models which can provide the information content of any physicochemical determinant used in property-based drug discovery; its application for the characterization of experimental polarity descriptors is discussed

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