Lyophilized bacterial extract OM 85-BV in the treatment of patients with chronic obstructive lung disease

Sa？etak The number and severity of its acute exacerbations determine in great extent the course of chronic obstructive pulmonary disease (COPD). Furthermore, the general efficacy of treatment of COPD depends significantly on the readiness and quality of cure of exacerbations. Although in the treatment of severe, most often bacterial exacerbations, different therapeutic measures are used, the rational choice of an antimicrobial has the pivotal role. The frequent use of antibiotics in patients with COPD can generate bacterial resistance to one or more antibiotics as well as an inappropriate immune response preparing the ground for re-infection. Therefore, the use of immunostimulants, such as purified bacterial extract OM 85-BV, should be considered, especially in frequent exacerbations. Based on results of performed clinical trials and the fact that each therapeutic measure, which diminishes the number, severity, and duration of COPD exacerbations, is welcome, we can consider OM 85-BV a potentially useful therapeutic modality for COPD patients, especially those with frequent bacterial exacerbations