The Treatment of Menorrhagia with Bioapigyn？ Herbal Ointment and Pessaries

Sa？etak The purpose of this work was the development and application of a new herbal ointment and pessaries for the topical treatment of menorrhagia using macerates and essential oils of medicinal plants as active ingredients. Fifty subjects with proven menorrhagia ranging from 32 to 54 years were divided into two groups (each had 25 participants) of similar age, health status and lifestyle. The first group used 2 g of ointment every eight hours while the second group used pessaries instead. The results were obtained at baseline and following the third menstrual cycle. In both groups a significant decrease was observed for all the symptoms (p<0.05). Significantly better results were obtained in the case of the ointment compared to the pessaries as expected due to the higher percentage of the active ingredients. The average duration of bleeding was reduced from 7.4 to 4.7 days in the case of the ointment and from 7.3 to 5.1 days in the group who used pessaries. The average number of painkillers is reduced from 22.1 to 10.6 and from 22.9 to 13.1 in the group using the ointment and pessaries, respectively. Decrease in other symptoms ranged from 71.4% up to 88.2% in the group using the ointment and from 57.3% to 73.7% in the case of pessaries usage. The obtained results could be correlated with the use of active ingredients with proven haemostatic, vasoconstrictor, astringent and spasmolytic activity