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-  2020 

PL-7 Antisynthetase Syndrome in Association with Sj?gren’s, Systemic Lupus Erythematosus, and Rheumatoid Arthritis

DOI: https://doi.org/10.1155/2020/4736476

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Abstract:

We present a rare case of PL-7 antisynthetase syndrome (ASS) in association with Sj?gren’s, systemic lupus erythematosus (SLE), and seropositive rheumatoid arthritis (RA). Initially, the patient was diagnosed with Sj?gren’s followed by Sj?gren’s/SLE overlap and then Sj?gren’s/SLE/RA overlap. She was eventually diagnosed with Sj?gren’s/SLE/RA overlap with PL-7 ASS with interstitial lung disease (ILD). ILD was discovered after complaints of pleuritic chest pain with subsequent workup with coronary computed tomography (CT) revealing pulmonary fibrosis. This case demonstrates the ambiguity with which symptoms of ASS can present; given the high respiratory morbidity and mortality of ASS especially in non-Jo-1 patients, those who present with Raynaud’s, myositis, or joint pain, whether together or in isolation, should be assessed for presence of additional features of ASS and potentially undergo testing for ASS antibodies if appropriate

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