Thermal Effects Associated with RF Exposures in Diagnostic MRI: Overview of Existing and Emerging Concepts of Protection

Apart from magnetic attraction risks, the primary biophysical concern associated with MRI is radiofrequency heating of the human body and associated discomfort, health deterioration, or potential burns. This paper reviews experimental data and numerical modeling of systemic (core and brain) temperature and local thermal effects associated with diagnostic MRI exposures at 1.5T (64 MHz) and 3.0T (128 MHz). Allowable temperatures and duration of systemic exposure are established based on knowledge of (short-term) human thermobiology. Longer term effects related to DNA damage or altered cellular pathways are not covered in this review. Updated limits are proposed for core temperature increase (≤1.3°C) and for Specific Absorption (<4 kJ/kg). The potential use of thermal dose (CEM43) for local thermal protection is described, and previously proposed exposure limit values are evaluated against available data from current MRI practice. Gaps in knowledge are identified, and recommendations for additional research are provided